The Daily Telegraph reported that “powerful painkillers used by thousands of arthritis sufferers almost double the chance of a patient suffering a heart attack and stroke”. The newspaper reports that the Cox-2 inhibitor Vioxx was withdrawn in 2004 after a study showed that it doubled the risk of heart attacks.
Rofecoxib is a nonsteroidal anti-inflammatory drug that is used to treat pain, particularly the pain of osteoarthritis and menstrual cramps.Prostaglandins are chemicals that are important in promoting inflammation and its signs--pain, fever, swelling and tenderness.Rofecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase- 2) and thereby reduces the amounts of prostaglandins.
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Rofecoxib should be used with caution in patients with fluid retention, hypertension or heart failure as fluid retention and edema has been observed in some patients. Rofecoxib should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other nonsteroidal anti-inflammatories. Severe.
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